Your Solution for 
Opioid-Sparing Surgeries

“This technology has allowed us to change our entire pain management protocol for TKAs; reducing the amount of opioids needed post-surgery and altering our physical therapy protocol to reach therapy goals earlier are just two of the resulting benefits”

Vinod Dasa, MD | Orthopedic Surgery, New Orleans, LA

Fewer Opioid Prescriptions

Fewer Opioids

Patients requested 45% fewer opioid prescriptions at 12 weeks after knee replacement surgery.1

Decreased Knee Pain

Decreased Knee Pain

More than 75% of patients reported decreased knee pain for up to 150 days.2

Less Stiffness

Faster Recovery

More than 50% of patients experienced less stiffness 12 weeks after treatment.1

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Less Pain,
Fewer Opioids

The iovera° system is a novel, long-lasting nerve block for perioperative and chronic pain. By applying intense cold to targeted nerves, the iovera° therapy prevents pain signals from being transmitted to the brain.

  • Non-systemic, non-opioid
  • Effective immediately after treatment (lasts up to 90 days)
  • Can treat superficial and deep nerves


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Dasa, V. et al. “Percutaneous freezing of sensory nerves prior to total knee arthroplasty.” The Knee (2016) p523-528.

2 Radnovich, R. et al. “Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial.” Osteoarthritis and Cartilage (2017) p1-10.